MaxQuant_1.6.2蛋白质谱分析软件.zip

上传者: 38744435 | 上传时间: 2025-10-04 15:16:11 | 文件大小: 124.55MB | 文件类型: ZIP
MaxQuant是一款广泛应用于蛋白质组学研究的开源软件,版本为1.6.2。它专为质谱数据处理和分析而设计,旨在帮助科学家从原始的RAW格式数据中提取、鉴定和定量蛋白质及其修饰。软件的功能强大且全面,涵盖了数据分析的多个关键步骤,包括质谱数据预处理、肽段鉴定、蛋白质识别、定量分析以及后续的生物信息学分析。 MaxQuant的核心功能是处理原始质谱数据。RAW文件是由质谱仪生成的未经处理的数据,包含了大量的信号强度信息。MaxQuant能够解析这些数据,提取出肽段离子的碎片信息,这是蛋白质鉴定的基础。这一过程通常涉及到峰检测、基线扣除、保留时间校正等步骤。 接下来,MaxQuant采用基于概率的模型进行肽段鉴定。它利用了Comet搜索引擎,对预先建立的蛋白质数据库进行搜索,比对碎片离子谱,以确定最可能的肽段序列。同时,MaxQuant还考虑了错配、氧化、乙酰化等常见的蛋白质修饰,进一步提高了鉴定的准确性。 在肽段鉴定的基础上,MaxQuant通过匹配同位素分布来实现蛋白质定量。这种方法称为“Isobaric Tags for Relative and Absolute Quantitation”(iTRAQ)或“Label-free quantitation”(LFQ)。前者依赖于不同同位素标记的肽段,后者则通过比较不同样本中相同肽段的强度来进行定量。 MaxQuant还允许用户自定义设置参数,以适应不同的实验条件和研究需求。例如,全局参数可以设定蛋白质和肽段的最低可信度阈值,以控制假阳性率;组特定参数则可以调整针对特定实验的特殊设定,如特定的修饰类型、酶切割规则等。此外,软件提供了丰富的性能和可视化配置,使用户能方便地监控分析进度,以及以图表形式展示结果,便于理解和解释数据。 MaxQuant 1.6.2是一个功能强大的蛋白质组分析工具,能够有效地处理复杂的质谱数据,进行精确的蛋白质鉴定和定量,为生物学研究提供重要的信息。其易用性、灵活性和准确性使其在蛋白质组学领域得到了广泛应用。无论是初学者还是经验丰富的研究人员,都能通过MaxQuant获得深入的蛋白质组学见解。

文件下载

资源详情

[{"title":"( 82 个子文件 124.55MB ) MaxQuant_1.6.2蛋白质谱分析软件.zip","children":[{"title":"MaxQuant","children":[{"title":"MaxQuant.exe <span style='color:#111;'> 195.50KB </span>","children":null,"spread":false},{"title":"bin","children":[{"title":"conf","children":[{"title":"annotation_config.xml <span style='color:#111;'> 3.74KB </span>","children":null,"spread":false},{"title":"uniprotSpecies.txt.gz <span style='color:#111;'> 3.38MB </span>","children":null,"spread":false},{"title":"maxquantAnnot.txt.gz <span style='color:#111;'> 86.19MB </span>","children":null,"spread":false},{"title":"modifications.xml <span style='color:#111;'> 351.94KB </span>","children":null,"spread":false},{"title":"databases.xml <span style='color:#111;'> 1.90MB </span>","children":null,"spread":false},{"title":"contaminants.fasta <span style='color:#111;'> 147.97KB </span>","children":null,"spread":false},{"title":"crosslinks.xml <span style='color:#111;'> 603B </span>","children":null,"spread":false},{"title":"enzymes.xml <span style='color:#111;'> 15.09KB </span>","children":null,"spread":false},{"title":"ibaq.txt <span style='color:#111;'> 741B </span>","children":null,"spread":false},{"title":"unexplainedPeaksNeg.txt <span style='color:#111;'> 783.06KB </span>","children":null,"spread":false},{"title":"compositions.txt <span style='color:#111;'> 935.90KB </span>","children":null,"spread":false},{"title":"spSpecies.txt <span style='color:#111;'> 12.90MB </span>","children":null,"spread":false},{"title":"unexplainedPeaksPos.txt <span style='color:#111;'> 1.20MB </span>","children":null,"spread":false}],"spread":false},{"title":"System.Data.SQLite.dll <span style='color:#111;'> 273.50KB </span>","children":null,"spread":false},{"title":"Tamir.SharpSSH.dll <span style='color:#111;'> 208.00KB </span>","children":null,"spread":false},{"title":"ThermoFisher.CommonCore.MassPrecisionEstimator.dll <span style='color:#111;'> 11.00KB </span>","children":null,"spread":false},{"title":"MSTS.xsd <span style='color:#111;'> 1.30KB </span>","children":null,"spread":false},{"title":"itextsharp.dll <span style='color:#111;'> 3.36MB </span>","children":null,"spread":false},{"title":"zlib.net.dll <span style='color:#111;'> 68.00KB </span>","children":null,"spread":false},{"title":"Org.Mentalis.Security.dll <span style='color:#111;'> 180.00KB </span>","children":null,"spread":false},{"title":"Devices.xsd <span style='color:#111;'> 1.43KB </span>","children":null,"spread":false},{"title":"Contents.xsd <span style='color:#111;'> 1.90KB </span>","children":null,"spread":false},{"title":"BaseCommon.dll <span style='color:#111;'> 285.00KB </span>","children":null,"spread":false},{"title":"UtilsWf.dll <span style='color:#111;'> 452.00KB </span>","children":null,"spread":false},{"title":"PluginRawMzXml.dll <span style='color:#111;'> 20.00KB </span>","children":null,"spread":false},{"title":"MassSpecDataReader.dll <span style='color:#111;'> 31.00KB </span>","children":null,"spread":false},{"title":"Clearcore2.Data.CommonInterfaces.dll <span style='color:#111;'> 20.00KB </span>","children":null,"spread":false},{"title":"MaxQuantLib.dll <span style='color:#111;'> 533.50KB </span>","children":null,"spread":false},{"title":"UtilsWpf.dll <span style='color:#111;'> 18.50KB </span>","children":null,"spread":false},{"title":"BaseLib.dll <span style='color:#111;'> 356.00KB </span>","children":null,"spread":false},{"title":"Clearcore2.Data.dll <span style='color:#111;'> 84.00KB </span>","children":null,"spread":false},{"title":"MSScan_XSpecific.xsd <span style='color:#111;'> 1.09KB </span>","children":null,"spread":false},{"title":"MsLibTask.exe <span style='color:#111;'> 5.50KB </span>","children":null,"spread":false},{"title":"DefaultMassCal.xsd <span style='color:#111;'> 2.44KB </span>","children":null,"spread":false},{"title":"baf2sql_c.dll <span style='color:#111;'> 8.76MB </span>","children":null,"spread":false},{"title":"PluginRawAgilent.dll <span style='color:#111;'> 8.50KB </span>","children":null,"spread":false},{"title":"Clearcore2.Muni.dll <span style='color:#111;'> 13.00KB </span>","children":null,"spread":false},{"title":"MaxQuantGui.exe <span style='color:#111;'> 383.50KB </span>","children":null,"spread":false},{"title":"Clearcore2.Data.WiffReader.dll <span style='color:#111;'> 155.50KB </span>","children":null,"spread":false},{"title":"Utils.dll <span style='color:#111;'> 4.05MB </span>","children":null,"spread":false},{"title":"Clearcore2.InternalRawXYProcessing.dll <span style='color:#111;'> 19.50KB </span>","children":null,"spread":false},{"title":"MaxQuantLibS.dll <span style='color:#111;'> 274.00KB </span>","children":null,"spread":false},{"title":"BaseError.dll <span style='color:#111;'> 9.50KB </span>","children":null,"spread":false},{"title":"PluginRawThermo2.dll <span style='color:#111;'> 15.50KB </span>","children":null,"spread":false},{"title":"ThermoFisher.CommonCore.BackgroundSubtraction.dll <span style='color:#111;'> 42.00KB </span>","children":null,"spread":false},{"title":"PluginRawSciex.dll <span style='color:#111;'> 16.00KB </span>","children":null,"spread":false},{"title":"Semver.dll <span style='color:#111;'> 9.50KB </span>","children":null,"spread":false},{"title":"BaseDataAccess.dll.config <span style='color:#111;'> 170B </span>","children":null,"spread":false},{"title":"MaxQuantTask.exe <span style='color:#111;'> 5.50KB </span>","children":null,"spread":false},{"title":"BaseLibS.dll <span style='color:#111;'> 24.50MB </span>","children":null,"spread":false},{"title":"MaxQuantServer.exe <span style='color:#111;'> 5.50KB </span>","children":null,"spread":false},{"title":"CommandLine.dll <span style='color:#111;'> 181.50KB </span>","children":null,"spread":false},{"title":"PluginRawBruker2.dll <span style='color:#111;'> 15.50KB </span>","children":null,"spread":false},{"title":"TeamCity.ServiceMessages.dll <span style='color:#111;'> 48.00KB </span>","children":null,"spread":false},{"title":"DiffieHellman.dll <span style='color:#111;'> 52.00KB </span>","children":null,"spread":false},{"title":"MaxQuantGui.exe.config <span style='color:#111;'> 559B </span>","children":null,"spread":false},{"title":"MaxQuantCmd.exe <span style='color:#111;'> 5.50KB </span>","children":null,"spread":false},{"title":"MaxQuantPLibS.dll <span style='color:#111;'> 1.37MB </span>","children":null,"spread":false},{"title":"BaseTof.dll <span style='color:#111;'> 1.11MB </span>","children":null,"spread":false},{"title":"agtsampleinforw.dll <span style='color:#111;'> 84.00KB </span>","children":null,"spread":false},{"title":"ThermoFisher.CommonCore.RawFileReader.dll <span style='color:#111;'> 629.50KB </span>","children":null,"spread":false},{"title":"MSActualDefs.xsd <span style='color:#111;'> 1.63KB </span>","children":null,"spread":false},{"title":"Clearcore2.RawXYProcessing.dll <span style='color:#111;'> 116.00KB </span>","children":null,"spread":false},{"title":"MSTS_XSpecific.xsd <span style='color:#111;'> 1.48KB </span>","children":null,"spread":false},{"title":"Clearcore2.ProjectUtilities.dll <span style='color:#111;'> 24.00KB </span>","children":null,"spread":false},{"title":"Clearcore2.Utility.dll <span style='color:#111;'> 80.00KB </span>","children":null,"spread":false},{"title":"Interop.MSFileReaderLib.dll <span style='color:#111;'> 59.50KB </span>","children":null,"spread":false},{"title":"SQLite.Interop.dll <span style='color:#111;'> 1014.50KB </span>","children":null,"spread":false},{"title":"MsLib.dll <span style='color:#111;'> 666.50KB </span>","children":null,"spread":false},{"title":"NumPluginBase2.dll <span style='color:#111;'> 16.50KB </span>","children":null,"spread":false},{"title":"MaxQuantRenderWpf.dll <span style='color:#111;'> 17.00KB </span>","children":null,"spread":false},{"title":"Clearcore2.StructuredStorage.dll <span style='color:#111;'> 28.00KB </span>","children":null,"spread":false},{"title":"BaseDataAccess.dll <span style='color:#111;'> 536.00KB </span>","children":null,"spread":false},{"title":"NumPluginSvm.dll <span style='color:#111;'> 44.00KB </span>","children":null,"spread":false},{"title":"MaxQuantPLib.dll <span style='color:#111;'> 767.50KB </span>","children":null,"spread":false},{"title":"ThermoFisher.CommonCore.Data.dll <span style='color:#111;'> 363.50KB </span>","children":null,"spread":false},{"title":"System.ValueTuple.dll <span style='color:#111;'> 77.35KB </span>","children":null,"spread":false},{"title":"CHANGELOG.md <span style='color:#111;'> 1.87KB </span>","children":null,"spread":false},{"title":"Clearcore2.Data.AnalystDataProvider.dll <span style='color:#111;'> 96.00KB </span>","children":null,"spread":false},{"title":"MqparConverter.exe <span style='color:#111;'> 11.50KB </span>","children":null,"spread":false},{"title":"NumPluginBase.dll <span style='color:#111;'> 40.00KB </span>","children":null,"spread":false}],"spread":false}],"spread":true}],"spread":true}]

评论信息

免责申明

【只为小站】的资源来自网友分享,仅供学习研究,请务必在下载后24小时内给予删除,不得用于其他任何用途,否则后果自负。基于互联网的特殊性,【只为小站】 无法对用户传输的作品、信息、内容的权属或合法性、合规性、真实性、科学性、完整权、有效性等进行实质审查;无论 【只为小站】 经营者是否已进行审查,用户均应自行承担因其传输的作品、信息、内容而可能或已经产生的侵权或权属纠纷等法律责任。
本站所有资源不代表本站的观点或立场,基于网友分享,根据中国法律《信息网络传播权保护条例》第二十二条之规定,若资源存在侵权或相关问题请联系本站客服人员,zhiweidada#qq.com,请把#换成@,本站将给予最大的支持与配合,做到及时反馈和处理。关于更多版权及免责申明参见 版权及免责申明